Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
| Uniprot primary ID | Q9HAZ1 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 121501 |
| GuidetoPHARMACOLOGY ID | 1993 |
| PharmGKB ID | PA26598 |
| KEGG ID | hsa:57396 |
| DIP ID | |
| STRING ID | 9606.ENSP00000316948 |
| IntAct ID | Q9HAZ1 |
| DMDM | 34922132 |
| BRENDA | |
| Reactome | |
| SignaLink | Q9HAZ1 |
| BioCyc | |
| Entrez Gene (Gene ID) | 57396 |
| BindingDB | Q9HAZ1 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.686 | 0.010 | 0.958 | 0.009 | 0.822 | 0.006 | 0.794 | 0.008 | 0.910 | 0.000 | 0.671 | 0.014 | Download |
| Estate fingerprints | 0.732 | 0.008 | 0.814 | 0.010 | 0.773 | 0.008 | 0.763 | 0.008 | 0.852 | 0.004 | 0.542 | 0.013 | Download |
| MACCS fingerprints | 0.703 | 0.005 | 0.875 | 0.009 | 0.789 | 0.007 | 0.769 | 0.007 | 0.882 | 0.004 | 0.582 | 0.011 | Download |
| Daylight fingerprints | 0.657 | 0.005 | 0.983 | 0.000 | 0.820 | 0.000 | 0.787 | 0.005 | 0.908 | 0.004 | 0.687 | 0.005 | Download |
| ECFP2 fingerprints | 0.731 | 0.012 | 0.911 | 0.005 | 0.821 | 0.007 | 0.805 | 0.008 | 0.904 | 0.005 | 0.657 | 0.013 | Download |
| ECFP4 fingerprints | 0.683 | 0.007 | 0.967 | 0.007 | 0.825 | 0.005 | 0.796 | 0.005 | 0.901 | 0.006 | 0.685 | 0.008 | Download |
| ECFP6 fingerprints | 0.651 | 0.003 | 0.989 | 0.003 | 0.820 | 0.000 | 0.790 | 0.000 | 0.893 | 0.008 | 0.690 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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