Target name

Q9HAZ1: Dual specificity protein kinase CLK4


  Protein function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

  Database links

Uniprot primary ID Q9HAZ1
PDB ID
DrugBank ID
BioGrid ID 121501
GuidetoPHARMACOLOGY ID 1993
PharmGKB ID PA26598
KEGG ID hsa:57396
DIP ID
STRING ID 9606.ENSP00000316948
IntAct ID Q9HAZ1
DMDM 34922132
BRENDA
Reactome
SignaLink Q9HAZ1
BioCyc
Entrez Gene (Gene ID) 57396
BindingDB Q9HAZ1

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.686 0.010 0.958 0.009 0.822 0.006 0.794 0.008 0.910 0.000 0.671 0.014 Download
Estate fingerprints 0.732 0.008 0.814 0.010 0.773 0.008 0.763 0.008 0.852 0.004 0.542 0.013 Download
MACCS fingerprints 0.703 0.005 0.875 0.009 0.789 0.007 0.769 0.007 0.882 0.004 0.582 0.011 Download
Daylight fingerprints 0.657 0.005 0.983 0.000 0.820 0.000 0.787 0.005 0.908 0.004 0.687 0.005 Download
ECFP2 fingerprints 0.731 0.012 0.911 0.005 0.821 0.007 0.805 0.008 0.904 0.005 0.657 0.013 Download
ECFP4 fingerprints 0.683 0.007 0.967 0.007 0.825 0.005 0.796 0.005 0.901 0.006 0.685 0.008 Download
ECFP6 fingerprints 0.651 0.003 0.989 0.003 0.820 0.000 0.790 0.000 0.893 0.008 0.690 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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