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E-mail: biomed@csu.edu.cn
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DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
| Uniprot primary ID | Q9HC16 |
| PDB ID | 3V4K 3V4J 3IR2 3IQS 2KBO 2JYW 4ROW 4ROV 3E1U 2KEM |
| DrugBank ID | |
| BioGrid ID | 121920 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA24897 |
| KEGG ID | hsa:60489 |
| DIP ID | DIP-37519N |
| STRING ID | 9606.ENSP00000385057 |
| IntAct ID | Q9HC16 |
| DMDM | 44887683 |
| BRENDA | 3.5.4.B9 |
| Reactome | R-HSA-180689 R-HSA-180585 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 60489 |
| BindingDB | Q9HC16 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.705 | 0.005 | 0.869 | 0.005 | 0.787 | 0.005 | 0.768 | 0.004 | 0.880 | 0.000 | 0.579 | 0.006 | Download |
| Estate fingerprints | 0.673 | 0.005 | 0.847 | 0.005 | 0.760 | 0.000 | 0.740 | 0.000 | 0.840 | 0.000 | 0.530 | 0.005 | Download |
| MACCS fingerprints | 0.706 | 0.007 | 0.804 | 0.004 | 0.755 | 0.005 | 0.741 | 0.003 | 0.850 | 0.000 | 0.514 | 0.005 | Download |
| Daylight fingerprints | 0.641 | 0.003 | 0.767 | 0.004 | 0.704 | 0.005 | 0.684 | 0.005 | 0.760 | 0.000 | 0.412 | 0.004 | Download |
| ECFP2 fingerprints | 0.846 | 0.005 | 0.912 | 0.005 | 0.879 | 0.003 | 0.873 | 0.005 | 0.950 | 0.000 | 0.758 | 0.006 | Download |
| ECFP4 fingerprints | 0.858 | 0.004 | 0.916 | 0.007 | 0.887 | 0.005 | 0.883 | 0.005 | 0.950 | 0.000 | 0.772 | 0.006 | Download |
| ECFP6 fingerprints | 0.832 | 0.004 | 0.924 | 0.003 | 0.878 | 0.004 | 0.871 | 0.003 | 0.946 | 0.005 | 0.759 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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