Target name

Q9HC16: DNA dC->dU-editing enzyme APOBEC-3G


  Protein function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.

  Database links

Uniprot primary ID Q9HC16
PDB ID 3V4K 3V4J 3IR2 3IQS 2KBO 2JYW 4ROW 4ROV 3E1U 2KEM
DrugBank ID
BioGrid ID 121920
GuidetoPHARMACOLOGY ID
PharmGKB ID PA24897
KEGG ID hsa:60489
DIP ID DIP-37519N
STRING ID 9606.ENSP00000385057
IntAct ID Q9HC16
DMDM 44887683
BRENDA 3.5.4.B9
Reactome R-HSA-180689 R-HSA-180585
SignaLink
BioCyc
Entrez Gene (Gene ID) 60489
BindingDB Q9HC16

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.705 0.005 0.869 0.005 0.787 0.005 0.768 0.004 0.880 0.000 0.579 0.006 Download
Estate fingerprints 0.673 0.005 0.847 0.005 0.760 0.000 0.740 0.000 0.840 0.000 0.530 0.005 Download
MACCS fingerprints 0.706 0.007 0.804 0.004 0.755 0.005 0.741 0.003 0.850 0.000 0.514 0.005 Download
Daylight fingerprints 0.641 0.003 0.767 0.004 0.704 0.005 0.684 0.005 0.760 0.000 0.412 0.004 Download
ECFP2 fingerprints 0.846 0.005 0.912 0.005 0.879 0.003 0.873 0.005 0.950 0.000 0.758 0.006 Download
ECFP4 fingerprints 0.858 0.004 0.916 0.007 0.887 0.005 0.883 0.005 0.950 0.000 0.772 0.006 Download
ECFP6 fingerprints 0.832 0.004 0.924 0.003 0.878 0.004 0.871 0.003 0.946 0.005 0.759 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn