Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
| Uniprot primary ID | Q9HC97 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 109117 |
| GuidetoPHARMACOLOGY ID | 102 |
| PharmGKB ID | PA28880 |
| KEGG ID | hsa:2859 |
| DIP ID | |
| STRING ID | 9606.ENSP00000415890 |
| IntAct ID | |
| DMDM | 68068087 |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2859 |
| BindingDB | Q9HC97 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.718 | 0.011 | 0.850 | 0.016 | 0.784 | 0.008 | 0.768 | 0.009 | 0.841 | 0.006 | 0.572 | 0.018 | Download |
| Estate fingerprints | 0.665 | 0.007 | 0.763 | 0.014 | 0.714 | 0.008 | 0.699 | 0.009 | 0.785 | 0.005 | 0.428 | 0.015 | Download |
| MACCS fingerprints | 0.720 | 0.015 | 0.732 | 0.021 | 0.726 | 0.013 | 0.724 | 0.011 | 0.783 | 0.008 | 0.453 | 0.023 | Download |
| Daylight fingerprints | 0.645 | 0.025 | 0.731 | 0.012 | 0.688 | 0.015 | 0.674 | 0.018 | 0.755 | 0.007 | 0.375 | 0.026 | Download |
| ECFP2 fingerprints | 0.780 | 0.012 | 0.816 | 0.012 | 0.798 | 0.012 | 0.794 | 0.010 | 0.884 | 0.007 | 0.594 | 0.022 | Download |
| ECFP4 fingerprints | 0.789 | 0.014 | 0.791 | 0.020 | 0.790 | 0.012 | 0.790 | 0.012 | 0.890 | 0.005 | 0.577 | 0.023 | Download |
| ECFP6 fingerprints | 0.764 | 0.018 | 0.844 | 0.013 | 0.804 | 0.010 | 0.795 | 0.010 | 0.905 | 0.007 | 0.609 | 0.018 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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