Target name

Q9HC97: G-protein coupled receptor 35


  Protein function

Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

  Database links

Uniprot primary ID Q9HC97
PDB ID
DrugBank ID
BioGrid ID 109117
GuidetoPHARMACOLOGY ID 102
PharmGKB ID PA28880
KEGG ID hsa:2859
DIP ID
STRING ID 9606.ENSP00000415890
IntAct ID
DMDM 68068087
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 2859
BindingDB Q9HC97

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.718 0.011 0.850 0.016 0.784 0.008 0.768 0.009 0.841 0.006 0.572 0.018 Download
Estate fingerprints 0.665 0.007 0.763 0.014 0.714 0.008 0.699 0.009 0.785 0.005 0.428 0.015 Download
MACCS fingerprints 0.720 0.015 0.732 0.021 0.726 0.013 0.724 0.011 0.783 0.008 0.453 0.023 Download
Daylight fingerprints 0.645 0.025 0.731 0.012 0.688 0.015 0.674 0.018 0.755 0.007 0.375 0.026 Download
ECFP2 fingerprints 0.780 0.012 0.816 0.012 0.798 0.012 0.794 0.010 0.884 0.007 0.594 0.022 Download
ECFP4 fingerprints 0.789 0.014 0.791 0.020 0.790 0.012 0.790 0.012 0.890 0.005 0.577 0.023 Download
ECFP6 fingerprints 0.764 0.018 0.844 0.013 0.804 0.010 0.795 0.010 0.905 0.007 0.609 0.018 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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