Target name

Q9JI35: Histamine H3 receptor


  Protein function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

  Database links

Uniprot primary ID Q9JI35
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10141.ENSCPOP00000020710
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 100135541
BindingDB Q9JI35

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.929 0.003 0.947 0.006 0.938 0.004 0.938 0.004 0.980 0.000 0.879 0.007 Download
Estate fingerprints 0.848 0.008 0.844 0.004 0.846 0.007 0.846 0.007 0.923 0.005 0.691 0.013 Download
MACCS fingerprints 0.899 0.006 0.899 0.005 0.899 0.003 0.899 0.003 0.960 0.000 0.797 0.007 Download
Daylight fingerprints 0.820 0.000 0.860 0.000 0.840 0.000 0.840 0.000 0.900 0.000 0.690 0.000 Download
ECFP2 fingerprints 0.974 0.007 0.940 0.005 0.957 0.005 0.957 0.005 0.990 0.000 0.912 0.004 Download
ECFP4 fingerprints 0.973 0.005 0.967 0.000 0.970 0.005 0.970 0.005 1.000 0.000 0.941 0.007 Download
ECFP6 fingerprints 0.966 0.005 0.980 0.000 0.973 0.005 0.973 0.005 1.000 0.000 0.947 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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