Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
| Uniprot primary ID | Q9NR96 |
| PDB ID | |
| DrugBank ID | DB00608 DB01611 |
| BioGrid ID | 119902 |
| GuidetoPHARMACOLOGY ID | 1759 |
| PharmGKB ID | PA38010 |
| KEGG ID | hsa:54106 |
| DIP ID | |
| STRING ID | 9606.ENSP00000417517 |
| IntAct ID | Q9NR96 |
| DMDM | 20140872 |
| BRENDA | |
| Reactome | R-HSA-109704 R-HSA-975138 R-HSA-975110 R-HSA-1679131 R-HSA-975155 R-HSA-168138 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 54106 |
| BindingDB | Q9NR96 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.811 | 0.009 | 0.771 | 0.008 | 0.791 | 0.009 | 0.797 | 0.008 | 0.880 | 0.000 | 0.587 | 0.013 | Download |
| Estate fingerprints | 0.712 | 0.008 | 0.758 | 0.011 | 0.735 | 0.007 | 0.726 | 0.007 | 0.816 | 0.005 | 0.468 | 0.014 | Download |
| MACCS fingerprints | 0.698 | 0.008 | 0.728 | 0.006 | 0.713 | 0.005 | 0.708 | 0.006 | 0.790 | 0.000 | 0.424 | 0.007 | Download |
| Daylight fingerprints | 0.699 | 0.009 | 0.721 | 0.007 | 0.710 | 0.005 | 0.709 | 0.006 | 0.750 | 0.000 | 0.422 | 0.006 | Download |
| ECFP2 fingerprints | 0.884 | 0.013 | 0.764 | 0.013 | 0.824 | 0.011 | 0.835 | 0.011 | 0.901 | 0.003 | 0.652 | 0.023 | Download |
| ECFP4 fingerprints | 0.932 | 0.008 | 0.740 | 0.015 | 0.836 | 0.008 | 0.849 | 0.006 | 0.934 | 0.005 | 0.685 | 0.014 | Download |
| ECFP6 fingerprints | 0.915 | 0.011 | 0.739 | 0.014 | 0.827 | 0.009 | 0.841 | 0.007 | 0.922 | 0.004 | 0.663 | 0.018 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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