Target name

Q9NR96: Toll-like receptor 9


  Protein function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

  Database links

Uniprot primary ID Q9NR96
PDB ID
DrugBank ID DB00608 DB01611
BioGrid ID 119902
GuidetoPHARMACOLOGY ID 1759
PharmGKB ID PA38010
KEGG ID hsa:54106
DIP ID
STRING ID 9606.ENSP00000417517
IntAct ID Q9NR96
DMDM 20140872
BRENDA
Reactome R-HSA-109704 R-HSA-975138 R-HSA-975110 R-HSA-1679131 R-HSA-975155 R-HSA-168138
SignaLink
BioCyc
Entrez Gene (Gene ID) 54106
BindingDB Q9NR96

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.811 0.009 0.771 0.008 0.791 0.009 0.797 0.008 0.880 0.000 0.587 0.013 Download
Estate fingerprints 0.712 0.008 0.758 0.011 0.735 0.007 0.726 0.007 0.816 0.005 0.468 0.014 Download
MACCS fingerprints 0.698 0.008 0.728 0.006 0.713 0.005 0.708 0.006 0.790 0.000 0.424 0.007 Download
Daylight fingerprints 0.699 0.009 0.721 0.007 0.710 0.005 0.709 0.006 0.750 0.000 0.422 0.006 Download
ECFP2 fingerprints 0.884 0.013 0.764 0.013 0.824 0.011 0.835 0.011 0.901 0.003 0.652 0.023 Download
ECFP4 fingerprints 0.932 0.008 0.740 0.015 0.836 0.008 0.849 0.006 0.934 0.005 0.685 0.014 Download
ECFP6 fingerprints 0.915 0.011 0.739 0.014 0.827 0.009 0.841 0.007 0.922 0.004 0.663 0.018 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn