The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
| Uniprot primary ID | Q9UBN7 |
| PDB ID | 3PHD 3GV4 3C5K |
| DrugBank ID | DB02546 |
| BioGrid ID | 115330 |
| GuidetoPHARMACOLOGY ID | 2618 |
| PharmGKB ID | PA29231 |
| KEGG ID | hsa:10013 |
| DIP ID | DIP-27544N |
| STRING ID | 9606.ENSP00000334061 |
| IntAct ID | Q9UBN7 |
| DMDM | 205371758 |
| BRENDA | 3.5.1.98 |
| Reactome | R-HSA-2122947 R-HSA-3371511 R-HSA-2894862 R-HSA-5617833 R-HSA-2644606 |
| SignaLink | Q9UBN7 |
| BioCyc | |
| Entrez Gene (Gene ID) | 10013 |
| BindingDB | Q9UBN7 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.884 | 0.007 | 0.882 | 0.005 | 0.883 | 0.005 | 0.883 | 0.005 | 0.950 | 0.000 | 0.765 | 0.005 | Download |
| Estate fingerprints | 0.846 | 0.005 | 0.756 | 0.003 | 0.801 | 0.003 | 0.810 | 0.000 | 0.880 | 0.000 | 0.605 | 0.007 | Download |
| MACCS fingerprints | 0.854 | 0.005 | 0.866 | 0.000 | 0.860 | 0.000 | 0.859 | 0.003 | 0.930 | 0.000 | 0.718 | 0.004 | Download |
| Daylight fingerprints | 0.673 | 0.005 | 0.777 | 0.003 | 0.725 | 0.005 | 0.709 | 0.003 | 0.780 | 0.000 | 0.450 | 0.005 | Download |
| ECFP2 fingerprints | 0.971 | 0.003 | 0.909 | 0.000 | 0.940 | 0.000 | 0.942 | 0.004 | 0.990 | 0.000 | 0.884 | 0.005 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.950 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.920 | 0.007 | Download |
| ECFP6 fingerprints | 0.946 | 0.005 | 0.972 | 0.005 | 0.959 | 0.003 | 0.958 | 0.004 | 0.990 | 0.000 | 0.917 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|