Target name

Q9UBN7: Histone deacetylase 6


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

  Database links

Uniprot primary ID Q9UBN7
PDB ID 3PHD 3GV4 3C5K
DrugBank ID DB02546
BioGrid ID 115330
GuidetoPHARMACOLOGY ID 2618
PharmGKB ID PA29231
KEGG ID hsa:10013
DIP ID DIP-27544N
STRING ID 9606.ENSP00000334061
IntAct ID Q9UBN7
DMDM 205371758
BRENDA 3.5.1.98
Reactome R-HSA-2122947 R-HSA-3371511 R-HSA-2894862 R-HSA-5617833 R-HSA-2644606
SignaLink Q9UBN7
BioCyc
Entrez Gene (Gene ID) 10013
BindingDB Q9UBN7

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.884 0.007 0.882 0.005 0.883 0.005 0.883 0.005 0.950 0.000 0.765 0.005 Download
Estate fingerprints 0.846 0.005 0.756 0.003 0.801 0.003 0.810 0.000 0.880 0.000 0.605 0.007 Download
MACCS fingerprints 0.854 0.005 0.866 0.000 0.860 0.000 0.859 0.003 0.930 0.000 0.718 0.004 Download
Daylight fingerprints 0.673 0.005 0.777 0.003 0.725 0.005 0.709 0.003 0.780 0.000 0.450 0.005 Download
ECFP2 fingerprints 0.971 0.003 0.909 0.000 0.940 0.000 0.942 0.004 0.990 0.000 0.884 0.005 Download
ECFP4 fingerprints 0.970 0.000 0.950 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.920 0.007 Download
ECFP6 fingerprints 0.946 0.005 0.972 0.005 0.959 0.003 0.958 0.004 0.990 0.000 0.917 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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