High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
| Uniprot primary ID | Q9UNQ0 |
| PDB ID | |
| DrugBank ID | DB00655 DB00158 DB00773 DB00619 DB00795 DB00220 DB08828 |
| BioGrid ID | 114821 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA390 |
| KEGG ID | hsa:9429 |
| DIP ID | DIP-29162N |
| STRING ID | 9606.ENSP00000237612 |
| IntAct ID | Q9UNQ0 |
| DMDM | 67462103 |
| BRENDA | |
| Reactome | R-HSA-2161517 R-HSA-917937 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 9429 |
| BindingDB | Q9UNQ0 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.836 | 0.007 | 0.868 | 0.005 | 0.852 | 0.004 | 0.849 | 0.003 | 0.910 | 0.000 | 0.703 | 0.007 | Download |
| Estate fingerprints | 0.841 | 0.009 | 0.809 | 0.000 | 0.825 | 0.005 | 0.828 | 0.006 | 0.891 | 0.003 | 0.653 | 0.009 | Download |
| MACCS fingerprints | 0.743 | 0.009 | 0.799 | 0.005 | 0.771 | 0.007 | 0.763 | 0.005 | 0.860 | 0.000 | 0.540 | 0.008 | Download |
| Daylight fingerprints | 0.778 | 0.006 | 0.806 | 0.005 | 0.792 | 0.004 | 0.786 | 0.005 | 0.826 | 0.005 | 0.581 | 0.006 | Download |
| ECFP2 fingerprints | 0.873 | 0.007 | 0.857 | 0.017 | 0.865 | 0.007 | 0.865 | 0.007 | 0.931 | 0.003 | 0.725 | 0.014 | Download |
| ECFP4 fingerprints | 0.830 | 0.005 | 0.912 | 0.006 | 0.871 | 0.003 | 0.867 | 0.005 | 0.929 | 0.003 | 0.746 | 0.010 | Download |
| ECFP6 fingerprints | 0.791 | 0.009 | 0.971 | 0.005 | 0.881 | 0.006 | 0.867 | 0.009 | 0.929 | 0.003 | 0.768 | 0.010 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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