Target name

Q9UNQ0: ATP-binding cassette sub-family G member 2


  Protein function

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.

  Database links

Uniprot primary ID Q9UNQ0
PDB ID
DrugBank ID DB00655 DB00158 DB00773 DB00619 DB00795 DB00220 DB08828
BioGrid ID 114821
GuidetoPHARMACOLOGY ID
PharmGKB ID PA390
KEGG ID hsa:9429
DIP ID DIP-29162N
STRING ID 9606.ENSP00000237612
IntAct ID Q9UNQ0
DMDM 67462103
BRENDA
Reactome R-HSA-2161517 R-HSA-917937
SignaLink
BioCyc
Entrez Gene (Gene ID) 9429
BindingDB Q9UNQ0

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.836 0.007 0.868 0.005 0.852 0.004 0.849 0.003 0.910 0.000 0.703 0.007 Download
Estate fingerprints 0.841 0.009 0.809 0.000 0.825 0.005 0.828 0.006 0.891 0.003 0.653 0.009 Download
MACCS fingerprints 0.743 0.009 0.799 0.005 0.771 0.007 0.763 0.005 0.860 0.000 0.540 0.008 Download
Daylight fingerprints 0.778 0.006 0.806 0.005 0.792 0.004 0.786 0.005 0.826 0.005 0.581 0.006 Download
ECFP2 fingerprints 0.873 0.007 0.857 0.017 0.865 0.007 0.865 0.007 0.931 0.003 0.725 0.014 Download
ECFP4 fingerprints 0.830 0.005 0.912 0.006 0.871 0.003 0.867 0.005 0.929 0.003 0.746 0.010 Download
ECFP6 fingerprints 0.791 0.009 0.971 0.005 0.881 0.006 0.867 0.009 0.929 0.003 0.768 0.010 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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