Target name

Q9Y233: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


  Protein function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

  Database links

Uniprot primary ID Q9Y233
PDB ID 3WYK 2OUY 2OUV 2OUU 2OUR 2OUS 2OUP 2OUQ 2OUN 3SN7 4MS0 3WS9 3WS8 4HF4 4MVH 4LKQ 4ZO5 4YS7 4DFF 4LM4 4DDL 4MRW 3UI7 4P0N 4WN1 4HEU 3SNL 3SNI 4LM3 4LM2 4LM1 4LM0 4MSE 4XY2 4TPP 3WYM 4TPM 4AJD 4AJG 4AJF 4YQH 4PHW 3UUO 2Y0J 2WEY 4AJM 3WI2 4LLP 4MUW 4MSC 3WYL
DrugBank ID DB00975 DB08811 DB08814 DB01113 DB00201
BioGrid ID 116057
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33120
KEGG ID hsa:10846
DIP ID
STRING ID 9606.ENSP00000438284
IntAct ID Q9Y233
DMDM 7993747
BRENDA 3.1.4.17
Reactome R-HSA-418457 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 10846
BindingDB Q9Y233

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.945 0.005 0.901 0.000 0.923 0.005 0.925 0.005 0.960 0.000 0.849 0.003 Download
Estate fingerprints 0.827 0.005 0.813 0.003 0.820 0.000 0.822 0.004 0.900 0.000 0.643 0.005 Download
MACCS fingerprints 0.880 0.000 0.854 0.005 0.867 0.005 0.870 0.000 0.940 0.000 0.734 0.005 Download
Daylight fingerprints 0.930 0.000 0.830 0.005 0.880 0.000 0.884 0.005 0.922 0.004 0.762 0.004 Download
ECFP2 fingerprints 0.952 0.004 0.924 0.000 0.938 0.004 0.939 0.003 0.980 0.000 0.873 0.005 Download
ECFP4 fingerprints 0.960 0.000 0.962 0.000 0.961 0.003 0.961 0.003 0.990 0.000 0.930 0.000 Download
ECFP6 fingerprints 0.933 0.005 0.987 0.005 0.960 0.000 0.958 0.004 0.990 0.000 0.918 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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