Target name

Q9Y243: RAC-gamma serine/threonine-protein kinase


  Protein function

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

  Database links

Uniprot primary ID Q9Y243
PDB ID 2X18
DrugBank ID
BioGrid ID 115318
GuidetoPHARMACOLOGY ID 2286
PharmGKB ID PA24686
KEGG ID hsa:10000
DIP ID DIP-32584N
STRING ID 9606.ENSP00000263826
IntAct ID Q9Y243
DMDM 12643943
BRENDA 2.7.11.1
Reactome R-HSA-111447 R-HSA-1358803 R-HSA-1257604 R-HSA-114604 R-HSA-198323 R-HSA-389513 R-HSA-199418 R-HSA-392451 R-HSA-5674400 R-HSA-198693 R-HSA-389357 R-HSA-5218920 R-HSA-5628897 R-HSA-211163
SignaLink Q9Y243
BioCyc
Entrez Gene (Gene ID) 10000
BindingDB Q9Y243

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.894 0.005 0.944 0.004 0.919 0.003 0.915 0.005 0.958 0.004 0.836 0.007 Download
Estate fingerprints 0.835 0.008 0.799 0.008 0.817 0.007 0.820 0.007 0.910 0.000 0.634 0.014 Download
MACCS fingerprints 0.919 0.006 0.773 0.009 0.846 0.005 0.856 0.005 0.936 0.005 0.706 0.005 Download
Daylight fingerprints 0.885 0.005 0.861 0.008 0.873 0.008 0.875 0.005 0.929 0.003 0.744 0.013 Download
ECFP2 fingerprints 0.906 0.005 0.936 0.007 0.921 0.003 0.919 0.003 0.970 0.000 0.842 0.006 Download
ECFP4 fingerprints 0.894 0.007 0.982 0.005 0.938 0.004 0.932 0.006 0.970 0.000 0.874 0.007 Download
ECFP6 fingerprints 0.897 0.007 0.999 0.000 0.948 0.004 0.940 0.005 0.962 0.004 0.897 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn