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E-mail: biomed@csu.edu.cn
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Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).
| Uniprot primary ID | Q9Y2R2 |
| PDB ID | 3OMH 3BRH 2QCJ 4J51 2QCT 2P6X 3OLR 3H2X |
| DrugBank ID | |
| BioGrid ID | 117604 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33995 |
| KEGG ID | hsa:26191 |
| DIP ID | DIP-29953N |
| STRING ID | 9606.ENSP00000352833 |
| IntAct ID | Q9Y2R2 |
| DMDM | 20139861 |
| BRENDA | 3.1.3.48 |
| Reactome | |
| SignaLink | Q9Y2R2 |
| BioCyc | |
| Entrez Gene (Gene ID) | 26191 |
| BindingDB | Q9Y2R2 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.623 | 0.008 | 0.963 | 0.003 | 0.793 | 0.007 | 0.750 | 0.008 | 0.903 | 0.005 | 0.621 | 0.009 | Download |
| Estate fingerprints | 0.820 | 0.008 | 0.812 | 0.007 | 0.816 | 0.008 | 0.817 | 0.009 | 0.882 | 0.004 | 0.633 | 0.016 | Download |
| MACCS fingerprints | 0.777 | 0.007 | 0.863 | 0.007 | 0.820 | 0.005 | 0.814 | 0.007 | 0.903 | 0.005 | 0.643 | 0.011 | Download |
| Daylight fingerprints | 0.603 | 0.005 | 0.917 | 0.008 | 0.760 | 0.005 | 0.712 | 0.006 | 0.823 | 0.005 | 0.544 | 0.013 | Download |
| ECFP2 fingerprints | 0.779 | 0.010 | 0.929 | 0.012 | 0.854 | 0.008 | 0.842 | 0.008 | 0.946 | 0.005 | 0.715 | 0.016 | Download |
| ECFP4 fingerprints | 0.738 | 0.015 | 0.982 | 0.003 | 0.860 | 0.008 | 0.840 | 0.011 | 0.946 | 0.005 | 0.737 | 0.014 | Download |
| ECFP6 fingerprints | 0.695 | 0.022 | 0.995 | 0.005 | 0.845 | 0.010 | 0.818 | 0.015 | 0.934 | 0.007 | 0.724 | 0.018 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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