Target name

Q9Y2R2: Tyrosine-protein phosphatase non-receptor type 22


  Protein function

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).

  Database links

Uniprot primary ID Q9Y2R2
PDB ID 3OMH 3BRH 2QCJ 4J51 2QCT 2P6X 3OLR 3H2X
DrugBank ID
BioGrid ID 117604
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33995
KEGG ID hsa:26191
DIP ID DIP-29953N
STRING ID 9606.ENSP00000352833
IntAct ID Q9Y2R2
DMDM 20139861
BRENDA 3.1.3.48
Reactome
SignaLink Q9Y2R2
BioCyc
Entrez Gene (Gene ID) 26191
BindingDB Q9Y2R2

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.623 0.008 0.963 0.003 0.793 0.007 0.750 0.008 0.903 0.005 0.621 0.009 Download
Estate fingerprints 0.820 0.008 0.812 0.007 0.816 0.008 0.817 0.009 0.882 0.004 0.633 0.016 Download
MACCS fingerprints 0.777 0.007 0.863 0.007 0.820 0.005 0.814 0.007 0.903 0.005 0.643 0.011 Download
Daylight fingerprints 0.603 0.005 0.917 0.008 0.760 0.005 0.712 0.006 0.823 0.005 0.544 0.013 Download
ECFP2 fingerprints 0.779 0.010 0.929 0.012 0.854 0.008 0.842 0.008 0.946 0.005 0.715 0.016 Download
ECFP4 fingerprints 0.738 0.015 0.982 0.003 0.860 0.008 0.840 0.011 0.946 0.005 0.737 0.014 Download
ECFP6 fingerprints 0.695 0.022 0.995 0.005 0.845 0.010 0.818 0.015 0.934 0.007 0.724 0.018 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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