Target name

Q9Y5X4: Photoreceptor-specific nuclear receptor


  Protein function

Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.

  Database links

Uniprot primary ID Q9Y5X4
PDB ID 4LOG
DrugBank ID
BioGrid ID 115320
GuidetoPHARMACOLOGY ID
PharmGKB ID PA31757
KEGG ID hsa:10002
DIP ID
STRING ID
IntAct ID Q9Y5X4
DMDM 8928275
BRENDA
Reactome R-HSA-383280
SignaLink Q9Y5X4
BioCyc
Entrez Gene (Gene ID) 10002
BindingDB Q9Y5X4

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.798 0.009 0.790 0.010 0.794 0.007 0.796 0.007 0.885 0.005 0.590 0.014 Download
Estate fingerprints 0.793 0.015 0.741 0.011 0.767 0.009 0.773 0.008 0.862 0.004 0.535 0.018 Download
MACCS fingerprints 0.759 0.009 0.781 0.010 0.770 0.007 0.766 0.008 0.832 0.006 0.538 0.015 Download
Daylight fingerprints 0.746 0.007 0.752 0.012 0.749 0.009 0.748 0.009 0.803 0.008 0.498 0.019 Download
ECFP2 fingerprints 0.899 0.010 0.733 0.014 0.816 0.010 0.830 0.008 0.903 0.005 0.640 0.019 Download
ECFP4 fingerprints 0.904 0.012 0.750 0.014 0.827 0.012 0.840 0.009 0.903 0.005 0.658 0.021 Download
ECFP6 fingerprints 0.852 0.010 0.760 0.010 0.806 0.005 0.814 0.005 0.892 0.004 0.614 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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