Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
| Uniprot primary ID | Q9Y5Y4 |
| PDB ID | |
| DrugBank ID | DB00328 DB00605 |
| BioGrid ID | 116412 |
| GuidetoPHARMACOLOGY ID | 339 |
| PharmGKB ID | PA28891 |
| KEGG ID | hsa:11251 |
| DIP ID | |
| STRING ID | 9606.ENSP00000332812 |
| IntAct ID | |
| DMDM | 296439334 |
| BRENDA | |
| Reactome | R-HSA-391908 R-HSA-418594 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 11251 |
| BindingDB | Q9Y5Y4 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.872 | 0.006 | 0.982 | 0.005 | 0.927 | 0.005 | 0.923 | 0.005 | 0.979 | 0.003 | 0.859 | 0.007 | Download |
| Estate fingerprints | 0.934 | 0.007 | 0.848 | 0.006 | 0.891 | 0.003 | 0.896 | 0.005 | 0.960 | 0.000 | 0.786 | 0.007 | Download |
| MACCS fingerprints | 0.882 | 0.004 | 0.916 | 0.007 | 0.899 | 0.003 | 0.898 | 0.004 | 0.960 | 0.000 | 0.800 | 0.007 | Download |
| Daylight fingerprints | 0.835 | 0.010 | 0.991 | 0.003 | 0.913 | 0.007 | 0.905 | 0.007 | 0.970 | 0.000 | 0.837 | 0.012 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.920 | 0.006 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.899 | 0.006 | Download |
| ECFP4 fingerprints | 0.969 | 0.003 | 0.983 | 0.003 | 0.976 | 0.005 | 0.976 | 0.005 | 0.990 | 0.000 | 0.949 | 0.006 | Download |
| ECFP6 fingerprints | 0.942 | 0.006 | 0.996 | 0.004 | 0.969 | 0.003 | 0.969 | 0.003 | 0.990 | 0.000 | 0.938 | 0.008 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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