Target name

Q9Y5Y4: Prostaglandin D2 receptor 2


  Protein function

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

  Database links

Uniprot primary ID Q9Y5Y4
PDB ID
DrugBank ID DB00328 DB00605
BioGrid ID 116412
GuidetoPHARMACOLOGY ID 339
PharmGKB ID PA28891
KEGG ID hsa:11251
DIP ID
STRING ID 9606.ENSP00000332812
IntAct ID
DMDM 296439334
BRENDA
Reactome R-HSA-391908 R-HSA-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 11251
BindingDB Q9Y5Y4

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.872 0.006 0.982 0.005 0.927 0.005 0.923 0.005 0.979 0.003 0.859 0.007 Download
Estate fingerprints 0.934 0.007 0.848 0.006 0.891 0.003 0.896 0.005 0.960 0.000 0.786 0.007 Download
MACCS fingerprints 0.882 0.004 0.916 0.007 0.899 0.003 0.898 0.004 0.960 0.000 0.800 0.007 Download
Daylight fingerprints 0.835 0.010 0.991 0.003 0.913 0.007 0.905 0.007 0.970 0.000 0.837 0.012 Download
ECFP2 fingerprints 0.980 0.000 0.920 0.006 0.950 0.000 0.950 0.000 0.990 0.000 0.899 0.006 Download
ECFP4 fingerprints 0.969 0.003 0.983 0.003 0.976 0.005 0.976 0.005 0.990 0.000 0.949 0.006 Download
ECFP6 fingerprints 0.942 0.006 0.996 0.004 0.969 0.003 0.969 0.003 0.990 0.000 0.938 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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