Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| Uniprot primary ID | Q9Y5Z0 |
| PDB ID | 3ZKG 3ZKI 3ZKN 3ZKM 3ZKS 4BFB 3ZKQ 4BEL 2EWY 3ZKX 3ZL7 3ZLQ |
| DrugBank ID | |
| BioGrid ID | 117353 |
| GuidetoPHARMACOLOGY ID | 2331 |
| PharmGKB ID | PA25233 |
| KEGG ID | hsa:25825 |
| DIP ID | |
| STRING ID | 9606.ENSP00000332979 |
| IntAct ID | |
| DMDM | 6685260 |
| BRENDA | 3.4.23.45 |
| Reactome | |
| SignaLink | |
| BioCyc | MetaCyc:G66-33964-MONOMER |
| Entrez Gene (Gene ID) | 25825 |
| BindingDB | Q9Y5Z0 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.901 | 0.003 | 0.989 | 0.005 | 0.945 | 0.005 | 0.940 | 0.000 | 0.970 | 0.000 | 0.890 | 0.007 | Download |
| Estate fingerprints | 0.854 | 0.007 | 0.802 | 0.005 | 0.828 | 0.006 | 0.834 | 0.005 | 0.910 | 0.000 | 0.658 | 0.009 | Download |
| MACCS fingerprints | 0.880 | 0.000 | 0.900 | 0.008 | 0.890 | 0.000 | 0.888 | 0.004 | 0.950 | 0.000 | 0.779 | 0.007 | Download |
| Daylight fingerprints | 0.894 | 0.005 | 0.944 | 0.003 | 0.919 | 0.003 | 0.918 | 0.004 | 0.940 | 0.000 | 0.839 | 0.006 | Download |
| ECFP2 fingerprints | 0.947 | 0.005 | 0.993 | 0.000 | 0.970 | 0.000 | 0.969 | 0.003 | 0.980 | 0.000 | 0.939 | 0.003 | Download |
| ECFP4 fingerprints | 0.959 | 0.003 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.952 | 0.004 | Download |
| ECFP6 fingerprints | 0.941 | 0.003 | 0.999 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.939 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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