Target name

Q9Y5Z0: Beta-secretase 2


  Protein function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

  Database links

Uniprot primary ID Q9Y5Z0
PDB ID 3ZKG 3ZKI 3ZKN 3ZKM 3ZKS 4BFB 3ZKQ 4BEL 2EWY 3ZKX 3ZL7 3ZLQ
DrugBank ID
BioGrid ID 117353
GuidetoPHARMACOLOGY ID 2331
PharmGKB ID PA25233
KEGG ID hsa:25825
DIP ID
STRING ID 9606.ENSP00000332979
IntAct ID
DMDM 6685260
BRENDA 3.4.23.45
Reactome
SignaLink
BioCyc MetaCyc:G66-33964-MONOMER
Entrez Gene (Gene ID) 25825
BindingDB Q9Y5Z0

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.901 0.003 0.989 0.005 0.945 0.005 0.940 0.000 0.970 0.000 0.890 0.007 Download
Estate fingerprints 0.854 0.007 0.802 0.005 0.828 0.006 0.834 0.005 0.910 0.000 0.658 0.009 Download
MACCS fingerprints 0.880 0.000 0.900 0.008 0.890 0.000 0.888 0.004 0.950 0.000 0.779 0.007 Download
Daylight fingerprints 0.894 0.005 0.944 0.003 0.919 0.003 0.918 0.004 0.940 0.000 0.839 0.006 Download
ECFP2 fingerprints 0.947 0.005 0.993 0.000 0.970 0.000 0.969 0.003 0.980 0.000 0.939 0.003 Download
ECFP4 fingerprints 0.959 0.003 1.000 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.952 0.004 Download
ECFP6 fingerprints 0.941 0.003 0.999 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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