Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
| Uniprot primary ID | O00763 |
| PDB ID | 2HJW 3GLK 3TDC 3JRW 3FF6 2DN8 4HQ6 3GID 2KCC 3JRX |
| DrugBank ID | DB00173 DB00121 |
| BioGrid ID | 106550 |
| GuidetoPHARMACOLOGY ID | 1264 |
| PharmGKB ID | PA24422 |
| KEGG ID | hsa:32 |
| DIP ID | DIP-51617N |
| STRING ID | 9606.ENSP00000341044 |
| IntAct ID | O00763 |
| DMDM | |
| BRENDA | 6.4.1.2 6.3.4.14 |
| Reactome | R-HSA-196780 R-HSA-163765 R-HSA-200425 R-HSA-3371599 R-HSA-2426168 |
| SignaLink | |
| BioCyc | MetaCyc:HS01211-MONOMER |
| Entrez Gene (Gene ID) | 32 |
| BindingDB | O00763 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.925 | 0.007 | 0.973 | 0.003 | 0.949 | 0.003 | 0.949 | 0.003 | 0.982 | 0.004 | 0.898 | 0.006 | Download |
| Estate fingerprints | 0.911 | 0.006 | 0.847 | 0.008 | 0.879 | 0.007 | 0.882 | 0.006 | 0.941 | 0.003 | 0.757 | 0.012 | Download |
| MACCS fingerprints | 0.916 | 0.005 | 0.864 | 0.007 | 0.890 | 0.000 | 0.894 | 0.005 | 0.960 | 0.000 | 0.780 | 0.009 | Download |
| Daylight fingerprints | 0.809 | 0.024 | 0.985 | 0.008 | 0.897 | 0.015 | 0.888 | 0.017 | 0.980 | 0.000 | 0.806 | 0.025 | Download |
| ECFP2 fingerprints | 0.968 | 0.004 | 0.972 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.941 | 0.003 | Download |
| ECFP4 fingerprints | 0.986 | 0.005 | 0.994 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.978 | 0.004 | Download |
| ECFP6 fingerprints | 0.955 | 0.005 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.961 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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