Target name

O00763: Acetyl-CoA carboxylase 2


  Protein function

Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).

  Database links

Uniprot primary ID O00763
PDB ID 2HJW 3GLK 3TDC 3JRW 3FF6 2DN8 4HQ6 3GID 2KCC 3JRX
DrugBank ID DB00173 DB00121
BioGrid ID 106550
GuidetoPHARMACOLOGY ID 1264
PharmGKB ID PA24422
KEGG ID hsa:32
DIP ID DIP-51617N
STRING ID 9606.ENSP00000341044
IntAct ID O00763
DMDM
BRENDA 6.4.1.2 6.3.4.14
Reactome R-HSA-196780 R-HSA-163765 R-HSA-200425 R-HSA-3371599 R-HSA-2426168
SignaLink
BioCyc MetaCyc:HS01211-MONOMER
Entrez Gene (Gene ID) 32
BindingDB O00763

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.925 0.007 0.973 0.003 0.949 0.003 0.949 0.003 0.982 0.004 0.898 0.006 Download
Estate fingerprints 0.911 0.006 0.847 0.008 0.879 0.007 0.882 0.006 0.941 0.003 0.757 0.012 Download
MACCS fingerprints 0.916 0.005 0.864 0.007 0.890 0.000 0.894 0.005 0.960 0.000 0.780 0.009 Download
Daylight fingerprints 0.809 0.024 0.985 0.008 0.897 0.015 0.888 0.017 0.980 0.000 0.806 0.025 Download
ECFP2 fingerprints 0.968 0.004 0.972 0.003 0.970 0.000 0.970 0.000 1.000 0.000 0.941 0.003 Download
ECFP4 fingerprints 0.986 0.005 0.994 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.978 0.004 Download
ECFP6 fingerprints 0.955 0.005 1.000 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.961 0.003 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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