Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
| Uniprot primary ID | O14684 |
| PDB ID | 4AL1 4AL0 4WAB 4YK5 3DWW 4BPM 4YL1 4YL0 4YL3 |
| DrugBank ID | |
| BioGrid ID | 114912 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33948 |
| KEGG ID | hsa:9536 |
| DIP ID | |
| STRING ID | 9606.ENSP00000342385 |
| IntAct ID | |
| DMDM | |
| BRENDA | 5.3.99.3 |
| Reactome | R-HSA-2162123 |
| SignaLink | |
| BioCyc | MetaCyc:HS07518-MONOMER |
| Entrez Gene (Gene ID) | 9536 |
| BindingDB | O14684 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.905 | 0.007 | 0.867 | 0.007 | 0.886 | 0.005 | 0.888 | 0.004 | 0.950 | 0.000 | 0.775 | 0.008 | Download |
| Estate fingerprints | 0.785 | 0.005 | 0.783 | 0.009 | 0.784 | 0.005 | 0.784 | 0.005 | 0.860 | 0.000 | 0.566 | 0.008 | Download |
| MACCS fingerprints | 0.778 | 0.009 | 0.738 | 0.005 | 0.758 | 0.006 | 0.762 | 0.008 | 0.839 | 0.003 | 0.515 | 0.012 | Download |
| Daylight fingerprints | 0.735 | 0.013 | 0.825 | 0.000 | 0.780 | 0.007 | 0.770 | 0.007 | 0.848 | 0.004 | 0.558 | 0.011 | Download |
| ECFP2 fingerprints | 0.964 | 0.007 | 0.856 | 0.008 | 0.910 | 0.005 | 0.917 | 0.007 | 0.980 | 0.000 | 0.827 | 0.011 | Download |
| ECFP4 fingerprints | 0.945 | 0.007 | 0.931 | 0.004 | 0.938 | 0.004 | 0.939 | 0.006 | 0.981 | 0.003 | 0.875 | 0.007 | Download |
| ECFP6 fingerprints | 0.906 | 0.008 | 0.968 | 0.005 | 0.937 | 0.005 | 0.931 | 0.006 | 0.980 | 0.000 | 0.868 | 0.009 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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