Target name

O14684: Prostaglandin E synthase


  Protein function

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).

  Database links

Uniprot primary ID O14684
PDB ID 4AL1 4AL0 4WAB 4YK5 3DWW 4BPM 4YL1 4YL0 4YL3
DrugBank ID
BioGrid ID 114912
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33948
KEGG ID hsa:9536
DIP ID
STRING ID 9606.ENSP00000342385
IntAct ID
DMDM
BRENDA 5.3.99.3
Reactome R-HSA-2162123
SignaLink
BioCyc MetaCyc:HS07518-MONOMER
Entrez Gene (Gene ID) 9536
BindingDB O14684

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.905 0.007 0.867 0.007 0.886 0.005 0.888 0.004 0.950 0.000 0.775 0.008 Download
Estate fingerprints 0.785 0.005 0.783 0.009 0.784 0.005 0.784 0.005 0.860 0.000 0.566 0.008 Download
MACCS fingerprints 0.778 0.009 0.738 0.005 0.758 0.006 0.762 0.008 0.839 0.003 0.515 0.012 Download
Daylight fingerprints 0.735 0.013 0.825 0.000 0.780 0.007 0.770 0.007 0.848 0.004 0.558 0.011 Download
ECFP2 fingerprints 0.964 0.007 0.856 0.008 0.910 0.005 0.917 0.007 0.980 0.000 0.827 0.011 Download
ECFP4 fingerprints 0.945 0.007 0.931 0.004 0.938 0.004 0.939 0.006 0.981 0.003 0.875 0.007 Download
ECFP6 fingerprints 0.906 0.008 0.968 0.005 0.937 0.005 0.931 0.006 0.980 0.000 0.868 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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