Target name

O14746: Telomerase reverse transcriptase


  Protein function

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

  Database links

Uniprot primary ID O14746
PDB ID 4MNQ 2BCK 4B18
DrugBank ID DB00495
BioGrid ID 112874
GuidetoPHARMACOLOGY ID
PharmGKB ID PA36447
KEGG ID hsa:7015
DIP ID DIP-40646N
STRING ID 9606.ENSP00000309572
IntAct ID O14746
DMDM
BRENDA
Reactome R-HSA-171319 R-HSA-201722
SignaLink
BioCyc
Entrez Gene (Gene ID) 7015
BindingDB O14746

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.869 0.003 0.953 0.006 0.911 0.003 0.908 0.004 0.955 0.005 0.828 0.006 Download
Estate fingerprints 0.835 0.010 0.761 0.006 0.798 0.004 0.806 0.005 0.869 0.003 0.600 0.011 Download
MACCS fingerprints 0.776 0.005 0.776 0.006 0.776 0.005 0.773 0.005 0.878 0.004 0.549 0.006 Download
Daylight fingerprints 0.712 0.006 0.812 0.003 0.762 0.004 0.750 0.005 0.821 0.003 0.530 0.008 Download
ECFP2 fingerprints 0.903 0.005 0.925 0.005 0.914 0.005 0.913 0.005 0.968 0.004 0.830 0.008 Download
ECFP4 fingerprints 0.886 0.005 0.972 0.005 0.929 0.003 0.925 0.005 0.970 0.000 0.861 0.007 Download
ECFP6 fingerprints 0.860 0.005 0.998 0.006 0.929 0.003 0.925 0.005 0.970 0.000 0.866 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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