G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
| Uniprot primary ID | O14842 |
| PDB ID | 4PHU |
| DrugBank ID | DB00159 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 225 |
| PharmGKB ID | PA28887 |
| KEGG ID | hsa:2864 |
| DIP ID | |
| STRING ID | 9606.ENSP00000246553 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-HSA-400511 R-HSA-381771 R-HSA-434316 R-HSA-444209 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2864 |
| BindingDB | O14842 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.948 | 0.004 | 0.946 | 0.003 | 0.947 | 0.005 | 0.947 | 0.005 | 0.970 | 0.000 | 0.890 | 0.000 | Download |
| Estate fingerprints | 0.953 | 0.005 | 0.869 | 0.005 | 0.911 | 0.006 | 0.914 | 0.005 | 0.962 | 0.004 | 0.826 | 0.010 | Download |
| MACCS fingerprints | 0.920 | 0.000 | 0.914 | 0.000 | 0.917 | 0.005 | 0.920 | 0.000 | 0.963 | 0.005 | 0.830 | 0.000 | Download |
| Daylight fingerprints | 0.808 | 0.004 | 0.832 | 0.000 | 0.820 | 0.000 | 0.819 | 0.003 | 0.870 | 0.000 | 0.640 | 0.005 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.960 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.940 | 0.005 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.970 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.945 | 0.005 | Download |
| ECFP6 fingerprints | 0.960 | 0.000 | 1.000 | 0.005 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.959 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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