Target name

O14842: Free fatty acid receptor 1


  Protein function

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

  Database links

Uniprot primary ID O14842
PDB ID 4PHU
DrugBank ID DB00159
BioGrid ID
GuidetoPHARMACOLOGY ID 225
PharmGKB ID PA28887
KEGG ID hsa:2864
DIP ID
STRING ID 9606.ENSP00000246553
IntAct ID
DMDM
BRENDA
Reactome R-HSA-400511 R-HSA-381771 R-HSA-434316 R-HSA-444209 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 2864
BindingDB O14842

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.948 0.004 0.946 0.003 0.947 0.005 0.947 0.005 0.970 0.000 0.890 0.000 Download
Estate fingerprints 0.953 0.005 0.869 0.005 0.911 0.006 0.914 0.005 0.962 0.004 0.826 0.010 Download
MACCS fingerprints 0.920 0.000 0.914 0.000 0.917 0.005 0.920 0.000 0.963 0.005 0.830 0.000 Download
Daylight fingerprints 0.808 0.004 0.832 0.000 0.820 0.000 0.819 0.003 0.870 0.000 0.640 0.005 Download
ECFP2 fingerprints 0.980 0.000 0.960 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.940 0.005 Download
ECFP4 fingerprints 0.970 0.000 0.970 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.945 0.005 Download
ECFP6 fingerprints 0.960 0.000 1.000 0.005 0.980 0.000 0.980 0.000 1.000 0.000 0.959 0.003 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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