Target name

O14920: Inhibitor of nuclear factor kappa-B kinase subunit beta


  Protein function

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

  Database links

Uniprot primary ID O14920
PDB ID 3BRT 3BRV 4KIK 4E3C
DrugBank ID DB00995 DB00945 DB01169 DB06151 DB00795 DB00244
BioGrid ID 109767
GuidetoPHARMACOLOGY ID 2039
PharmGKB ID PA29776
KEGG ID hsa:3551
DIP ID DIP-27527N
STRING ID 9606.ENSP00000430684
IntAct ID O14920
DMDM
BRENDA 2.7.11.10
Reactome R-HSA-933542 R-HSA-933543 R-HSA-202424 R-HSA-5602636 R-HSA-5603029 R-HSA-2871837 R-HSA-168638 R-HSA-975144 R-HSA-445989 R-HSA-1810476 R-HSA-209543 R-HSA-209560 R-HSA-5603027 R-HSA-1169091 R-HSA-937039 R-HSA-5607764 R-HSA-937041 R-HSA-446652
SignaLink O14920
BioCyc
Entrez Gene (Gene ID) 3551
BindingDB O14920

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.823 0.005 0.915 0.003 0.869 0.003 0.860 0.000 0.930 0.000 0.737 0.005 Download
Estate fingerprints 0.865 0.005 0.795 0.000 0.830 0.000 0.831 0.003 0.890 0.000 0.658 0.004 Download
MACCS fingerprints 0.849 0.006 0.781 0.005 0.815 0.005 0.823 0.005 0.890 0.000 0.632 0.008 Download
Daylight fingerprints 0.767 0.005 0.739 0.003 0.753 0.005 0.759 0.003 0.810 0.000 0.509 0.006 Download
ECFP2 fingerprints 0.941 0.003 0.899 0.003 0.920 0.000 0.922 0.004 0.970 0.000 0.847 0.005 Download
ECFP4 fingerprints 0.940 0.000 0.960 0.003 0.950 0.000 0.950 0.000 0.980 0.000 0.909 0.003 Download
ECFP6 fingerprints 0.929 0.003 0.973 0.003 0.951 0.003 0.950 0.000 0.980 0.000 0.908 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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