Target name

O15379: Histone deacetylase 3


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).

  Database links

Uniprot primary ID O15379
PDB ID 4A69
DrugBank ID DB02546
BioGrid ID 114368
GuidetoPHARMACOLOGY ID 2617
PharmGKB ID PA29228
KEGG ID hsa:8841
DIP ID DIP-24253N
STRING ID 9606.ENSP00000302967
IntAct ID O15379
DMDM
BRENDA
Reactome R-HSA-1989781 R-HSA-400253 R-HSA-1368082 R-HSA-1368071 R-HSA-400206 R-HSA-381340 R-HSA-2151201 R-HSA-193670 R-HSA-2122947 R-HSA-3214815 R-HSA-2644606 R-HSA-1368108 R-HSA-2894862
SignaLink O15379
BioCyc
Entrez Gene (Gene ID) 8841
BindingDB O15379

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.845 0.011 0.913 0.010 0.879 0.009 0.877 0.009 0.950 0.000 0.763 0.016 Download
Estate fingerprints 0.909 0.007 0.741 0.006 0.825 0.005 0.838 0.004 0.900 0.000 0.659 0.009 Download
MACCS fingerprints 0.812 0.006 0.864 0.004 0.838 0.004 0.835 0.005 0.930 0.000 0.677 0.008 Download
Daylight fingerprints 0.755 0.008 0.743 0.006 0.749 0.003 0.752 0.006 0.800 0.000 0.499 0.010 Download
ECFP2 fingerprints 0.977 0.005 0.899 0.007 0.938 0.004 0.939 0.003 0.981 0.003 0.875 0.008 Download
ECFP4 fingerprints 0.969 0.003 0.933 0.005 0.951 0.003 0.951 0.003 0.990 0.000 0.902 0.004 Download
ECFP6 fingerprints 0.936 0.010 0.950 0.006 0.943 0.007 0.943 0.007 0.990 0.000 0.885 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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