TargetNet
  Target name

O43613: Orexin receptor type 1

  Protein function

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

  Database links
Uniprot primary ID O43613
PDB ID
DrugBank ID DB09034
BioGrid ID 109311
GuidetoPHARMACOLOGY ID 321
PharmGKB ID PA29222
KEGG ID hsa:3061
DIP ID
STRING ID 9606.ENSP00000362810
IntAct ID
DMDM
BRENDA
Reactome R-HSA-389397 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 3061
BindingDB O43613
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.695 0.005 0.845 0.005 0.770 0.000 0.750 0.000 0.831 0.003 0.546 0.005 Download
Estate fingerprints 0.699 0.006 0.715 0.005 0.707 0.005 0.703 0.005 0.790 0.000 0.410 0.007 Download
MACCS fingerprints 0.690 0.000 0.670 0.009 0.680 0.000 0.683 0.005 0.753 0.005 0.359 0.009 Download
Daylight fingerprints 0.679 0.003 0.743 0.005 0.711 0.003 0.702 0.004 0.759 0.003 0.427 0.005 Download
ECFP2 fingerprints 0.791 0.009 0.883 0.008 0.837 0.005 0.828 0.006 0.920 0.000 0.674 0.012 Download
ECFP4 fingerprints 0.719 0.006 0.961 0.003 0.840 0.000 0.818 0.004 0.930 0.000 0.695 0.005 Download
ECFP6 fingerprints 0.663 0.005 0.979 0.005 0.821 0.003 0.789 0.003 0.925 0.005 0.679 0.006 Download
  Download datasets
Positive dataset Negative dataset

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn