Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
| Uniprot primary ID | O95977 |
| PDB ID | 2DCO |
| DrugBank ID | |
| BioGrid ID | 114243 |
| GuidetoPHARMACOLOGY ID | 278 |
| PharmGKB ID | PA162402371 |
| KEGG ID | hsa:8698 |
| DIP ID | |
| STRING ID | 9606.ENSP00000246115 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-HSA-419408 R-HSA-418594 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 8698 |
| BindingDB | O95977 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.899 | 0.003 | 0.951 | 0.007 | 0.925 | 0.005 | 0.921 | 0.003 | 0.960 | 0.000 | 0.849 | 0.006 | Download |
| Estate fingerprints | 0.808 | 0.008 | 0.838 | 0.006 | 0.823 | 0.005 | 0.821 | 0.006 | 0.906 | 0.005 | 0.645 | 0.007 | Download |
| MACCS fingerprints | 0.891 | 0.009 | 0.841 | 0.008 | 0.866 | 0.007 | 0.871 | 0.006 | 0.930 | 0.000 | 0.736 | 0.012 | Download |
| Daylight fingerprints | 0.780 | 0.008 | 0.820 | 0.006 | 0.800 | 0.005 | 0.798 | 0.008 | 0.859 | 0.003 | 0.602 | 0.011 | Download |
| ECFP2 fingerprints | 0.907 | 0.005 | 0.931 | 0.000 | 0.919 | 0.003 | 0.918 | 0.004 | 0.970 | 0.000 | 0.838 | 0.006 | Download |
| ECFP4 fingerprints | 0.904 | 0.005 | 0.956 | 0.004 | 0.930 | 0.000 | 0.930 | 0.000 | 0.976 | 0.005 | 0.862 | 0.004 | Download |
| ECFP6 fingerprints | 0.906 | 0.005 | 0.958 | 0.005 | 0.932 | 0.004 | 0.931 | 0.003 | 0.979 | 0.003 | 0.869 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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