Target name

O95977: Sphingosine 1-phosphate receptor 4


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

  Database links

Uniprot primary ID O95977
PDB ID 2DCO
DrugBank ID
BioGrid ID 114243
GuidetoPHARMACOLOGY ID 278
PharmGKB ID PA162402371
KEGG ID hsa:8698
DIP ID
STRING ID 9606.ENSP00000246115
IntAct ID
DMDM
BRENDA
Reactome R-HSA-419408 R-HSA-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 8698
BindingDB O95977

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.003 0.951 0.007 0.925 0.005 0.921 0.003 0.960 0.000 0.849 0.006 Download
Estate fingerprints 0.808 0.008 0.838 0.006 0.823 0.005 0.821 0.006 0.906 0.005 0.645 0.007 Download
MACCS fingerprints 0.891 0.009 0.841 0.008 0.866 0.007 0.871 0.006 0.930 0.000 0.736 0.012 Download
Daylight fingerprints 0.780 0.008 0.820 0.006 0.800 0.005 0.798 0.008 0.859 0.003 0.602 0.011 Download
ECFP2 fingerprints 0.907 0.005 0.931 0.000 0.919 0.003 0.918 0.004 0.970 0.000 0.838 0.006 Download
ECFP4 fingerprints 0.904 0.005 0.956 0.004 0.930 0.000 0.930 0.000 0.976 0.005 0.862 0.004 Download
ECFP6 fingerprints 0.906 0.005 0.958 0.005 0.932 0.004 0.931 0.003 0.979 0.003 0.869 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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