Target name

P00491: Purine nucleoside phosphorylase


  Protein function

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

  Database links

Uniprot primary ID P00491
PDB ID 1V45 1V41 1PWY 4GKA 1RFG 3D1V 1V3Q 2OC9 3INY 2OC4 2Q7O 1M73 1RT9 1YRY 3PHB 3GGS 1RR6 2A0Y 2A0X 4EAR 2A0W 1RCT 3BGS 4ECE 1ULB 1PF7 1ULA 3K8O 4EB8 1RSZ 3GB9 1V2H 2ON6 3K8Q
DrugBank ID DB00242 DB00900
BioGrid ID 110921
GuidetoPHARMACOLOGY ID 2841
PharmGKB ID PA31694
KEGG ID hsa:4860
DIP ID DIP-50406N
STRING ID 9606.ENSP00000354532
IntAct ID P00491
DMDM 108935929
BRENDA 2.4.2.1
Reactome R-HSA-74217 R-HSA-74259
SignaLink P00491
BioCyc MetaCyc:HS02151-MONOMER
Entrez Gene (Gene ID) 4860
BindingDB P00491

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.989 0.003 0.991 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.989 0.003 Download
Estate fingerprints 0.980 0.007 0.936 0.006 0.958 0.006 0.961 0.003 0.990 0.000 0.921 0.009 Download
MACCS fingerprints 1.000 0.000 0.980 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
Daylight fingerprints 0.866 0.005 0.994 0.000 0.930 0.000 0.930 0.000 1.000 0.000 0.870 0.000 Download
ECFP2 fingerprints 1.000 0.000 0.980 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.975 0.005 Download
ECFP4 fingerprints 1.000 0.000 0.990 0.004 0.995 0.005 0.995 0.005 1.000 0.000 0.988 0.004 Download
ECFP6 fingerprints 1.000 0.000 1.000 0.005 1.000 0.000 1.000 0.000 1.000 0.000 0.997 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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