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E-mail: biomed@csu.edu.cn
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Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
| Uniprot primary ID | P00734 |
| PDB ID | 1GHX 1GHY 1TOM 3P17 1GHV 1GHW 1C1W 1C1V 1C1U 3D49 3QGN 3VXF 3VXE 2BVX 1AE8 4DT7 2ANM 1SFQ 2ANK 1DWB 1DWC 1BMM 1DWD 1DWE 1QHR 3DT0 1IHT 3LU9 1IHS 2ZHF 4N3L 2A0Q 1D3Q 1XMN 1C4Y 7KME 4UDW 2UUF 2ZHW 1K22 2UUJ 2UUK 1C4U 1C4V 1RD3 2THF 3QLP 1SB1 5AHG 3BF6 1E0F |
| DrugBank ID | DB00100 DB04786 DB04898 DB00278 DB00055 DB01123 DB00006 |
| BioGrid ID | 108447 |
| GuidetoPHARMACOLOGY ID | 2362 |
| PharmGKB ID | PA157 |
| KEGG ID | hsa:2147 |
| DIP ID | DIP-6115N |
| STRING ID | 9606.ENSP00000308541 |
| IntAct ID | P00734 |
| DMDM | 135807 |
| BRENDA | 3.4.21.5 |
| Reactome | R-HSA-159740 R-HSA-381426 R-HSA-76009 R-HSA-456926 R-HSA-375276 R-HSA-202733 R-HSA-416476 R-HSA-159782 R-HSA-140837 R-HSA-140875 R-HSA-159763 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2147 |
| BindingDB | P00734 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.724 | 0.005 | 0.836 | 0.000 | 0.780 | 0.000 | 0.770 | 0.000 | 0.870 | 0.000 | 0.570 | 0.000 | Download |
| Estate fingerprints | 0.786 | 0.005 | 0.854 | 0.000 | 0.820 | 0.000 | 0.820 | 0.000 | 0.900 | 0.000 | 0.650 | 0.000 | Download |
| MACCS fingerprints | 0.758 | 0.004 | 0.822 | 0.000 | 0.790 | 0.000 | 0.780 | 0.000 | 0.860 | 0.000 | 0.579 | 0.003 | Download |
| Daylight fingerprints | 0.729 | 0.003 | 0.793 | 0.000 | 0.761 | 0.003 | 0.755 | 0.005 | 0.800 | 0.000 | 0.530 | 0.000 | Download |
| ECFP2 fingerprints | 0.850 | 0.000 | 0.912 | 0.000 | 0.881 | 0.003 | 0.880 | 0.000 | 0.950 | 0.000 | 0.770 | 0.000 | Download |
| ECFP4 fingerprints | 0.860 | 0.000 | 0.960 | 0.000 | 0.910 | 0.000 | 0.900 | 0.000 | 0.960 | 0.000 | 0.818 | 0.004 | Download |
| ECFP6 fingerprints | 0.850 | 0.000 | 0.950 | 0.000 | 0.900 | 0.000 | 0.896 | 0.005 | 0.960 | 0.000 | 0.808 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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