Target name

P00734: Prothrombin


  Protein function

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

  Database links

Uniprot primary ID P00734
PDB ID 1GHX 1GHY 1TOM 3P17 1GHV 1GHW 1C1W 1C1V 1C1U 3D49 3QGN 3VXF 3VXE 2BVX 1AE8 4DT7 2ANM 1SFQ 2ANK 1DWB 1DWC 1BMM 1DWD 1DWE 1QHR 3DT0 1IHT 3LU9 1IHS 2ZHF 4N3L 2A0Q 1D3Q 1XMN 1C4Y 7KME 4UDW 2UUF 2ZHW 1K22 2UUJ 2UUK 1C4U 1C4V 1RD3 2THF 3QLP 1SB1 5AHG 3BF6 1E0F
DrugBank ID DB00100 DB04786 DB04898 DB00278 DB00055 DB01123 DB00006
BioGrid ID 108447
GuidetoPHARMACOLOGY ID 2362
PharmGKB ID PA157
KEGG ID hsa:2147
DIP ID DIP-6115N
STRING ID 9606.ENSP00000308541
IntAct ID P00734
DMDM 135807
BRENDA 3.4.21.5
Reactome R-HSA-159740 R-HSA-381426 R-HSA-76009 R-HSA-456926 R-HSA-375276 R-HSA-202733 R-HSA-416476 R-HSA-159782 R-HSA-140837 R-HSA-140875 R-HSA-159763
SignaLink
BioCyc
Entrez Gene (Gene ID) 2147
BindingDB P00734

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.724 0.005 0.836 0.000 0.780 0.000 0.770 0.000 0.870 0.000 0.570 0.000 Download
Estate fingerprints 0.786 0.005 0.854 0.000 0.820 0.000 0.820 0.000 0.900 0.000 0.650 0.000 Download
MACCS fingerprints 0.758 0.004 0.822 0.000 0.790 0.000 0.780 0.000 0.860 0.000 0.579 0.003 Download
Daylight fingerprints 0.729 0.003 0.793 0.000 0.761 0.003 0.755 0.005 0.800 0.000 0.530 0.000 Download
ECFP2 fingerprints 0.850 0.000 0.912 0.000 0.881 0.003 0.880 0.000 0.950 0.000 0.770 0.000 Download
ECFP4 fingerprints 0.860 0.000 0.960 0.000 0.910 0.000 0.900 0.000 0.960 0.000 0.818 0.004 Download
ECFP6 fingerprints 0.850 0.000 0.950 0.000 0.900 0.000 0.896 0.005 0.960 0.000 0.808 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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