Target name

P00749: Urokinase-type plasminogen activator


  Protein function

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

  Database links

Uniprot primary ID P00749
PDB ID 1OWI 1OWH 4ZHL 4ZHM 1OWE 1OWD 1VJA 1OWJ 1URK 1C5Z 1C5Y 1C5X 4K24 1F5L 4FUB 1C5W 3OY5 1O3P 1GJD 3OY6 1GJB 1FV9 1GJA 3KHV 4JK6 4JK5 3M61 4JNL 4OS2 1SC8 1U6Q 1GJ9 1GI7 1W14 3U73 1GJ7 1GI8 1GJ8 1GJC 4X1R 1SQT 1F92 1F5K 2I9B 4MNX 1OWK 1KDU 1SQA 4JNI 1SQO 4X1N
DrugBank ID DB00013 DB00594
BioGrid ID 111344
GuidetoPHARMACOLOGY ID 2393
PharmGKB ID PA33382
KEGG ID hsa:5328
DIP ID DIP-46387N
STRING ID 9606.ENSP00000361850
IntAct ID P00749
DMDM 254763341
BRENDA 3.4.21.73
Reactome R-HSA-75205
SignaLink
BioCyc
Entrez Gene (Gene ID) 5328
BindingDB P00749

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.867 0.005 0.913 0.004 0.890 0.000 0.888 0.004 0.950 0.000 0.780 0.007 Download
Estate fingerprints 0.850 0.000 0.930 0.000 0.890 0.000 0.889 0.003 0.966 0.005 0.784 0.005 Download
MACCS fingerprints 0.841 0.003 0.899 0.000 0.870 0.000 0.869 0.003 0.930 0.000 0.748 0.004 Download
Daylight fingerprints 0.805 0.005 0.787 0.005 0.796 0.005 0.799 0.003 0.850 0.000 0.593 0.005 Download
ECFP2 fingerprints 0.940 0.000 0.960 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.901 0.003 Download
ECFP4 fingerprints 0.958 0.006 0.966 0.000 0.962 0.004 0.962 0.004 0.990 0.000 0.929 0.003 Download
ECFP6 fingerprints 0.940 0.005 0.980 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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