Target name

P00797: Renin


  Protein function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

  Database links

Uniprot primary ID P00797
PDB ID 3KM4 1BBS 3K1W 4Q1N 2IKO 3OAG 3Q5H 4XX4 2V0Z 3Q3T 2IKU 4S1G 2FS4 3G6Z 4RYG 4AMT 4GJ5 2V16 4GJ7 4GJ6 2V13 2V12 1RNE 2V10 4GJ9 4GJ8 2I4Q 3G72 2BKS 3G70 2BKT 3OQK 3OAD 3OQF 3OWN 3Q4B 3VCM 2IL2 2X0B 3OOT 2G1N 2G1O 3SFC 2G1R 4GJD 4GJC 4RZ1 3VSX 2REN 1HRN 3D91
DrugBank ID DB00212
BioGrid ID 111904
GuidetoPHARMACOLOGY ID 2413
PharmGKB ID PA297
KEGG ID hsa:5972
DIP ID DIP-59219N
STRING ID 9606.ENSP00000272190
IntAct ID P00797
DMDM 132326
BRENDA 3.4.23.15
Reactome R-HSA-2022377
SignaLink
BioCyc
Entrez Gene (Gene ID) 5972
BindingDB P00797

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.850 0.000 0.910 0.000 0.880 0.000 0.879 0.003 0.950 0.000 0.760 0.000 Download
Estate fingerprints 0.860 0.000 0.780 0.000 0.820 0.000 0.830 0.000 0.900 0.000 0.643 0.005 Download
MACCS fingerprints 0.860 0.000 0.860 0.000 0.860 0.000 0.860 0.000 0.940 0.000 0.729 0.003 Download
Daylight fingerprints 0.794 0.005 0.926 0.000 0.860 0.000 0.850 0.000 0.930 0.000 0.730 0.000 Download
ECFP2 fingerprints 0.920 0.000 0.960 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.880 0.000 Download
ECFP4 fingerprints 0.939 0.003 0.981 0.000 0.960 0.000 0.959 0.003 0.990 0.000 0.912 0.004 Download
ECFP6 fingerprints 0.871 0.003 0.989 0.000 0.930 0.000 0.920 0.000 0.990 0.000 0.860 0.000 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn