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E-mail: biomed@csu.edu.cn
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Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
| Uniprot primary ID | P00918 |
| PDB ID | 4E49 4ZWI 2AW1 4Q9Y 3K7K 1ZFQ 3P5A 4ZWZ 4ZWY 3N0N 1BV3 3M1K 1FQR 3M1Q 4Q6D 3M1W 1ZFK 3ZP9 1LG6 1BNN 3U7C 1LG5 1FQN 1FQL 1FQM 4Q49 4MO8 3P5L 3V5G 1CIM 1LGD 3CYU 3M14 3SBH 3SBI 5BRW 1CIN 4KUV 1CIL 3S9T 3ML2 2WEG 1BIC 3KKX 4Q90 2H15 2EU2 2EU3 3M1J 1UGF 4HBA |
| DrugBank ID | DB01119 DB01144 DB01194 DB00695 DB01021 DB01031 DB00880 |
| BioGrid ID | 107215 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA25989 |
| KEGG ID | hsa:760 |
| DIP ID | |
| STRING ID | 9606.ENSP00000285379 |
| IntAct ID | P00918 |
| DMDM | |
| BRENDA | 4.2.1.1 |
| Reactome | R-HSA-1247673 R-HSA-1237044 R-HSA-1475029 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 760 |
| BindingDB | P00918 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.910 | 0.000 | 0.910 | 0.000 | 0.910 | 0.000 | 0.910 | 0.000 | 0.960 | 0.000 | 0.819 | 0.003 | Download |
| Estate fingerprints | 0.910 | 0.000 | 0.930 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.970 | 0.000 | 0.840 | 0.000 | Download |
| MACCS fingerprints | 0.903 | 0.005 | 0.877 | 0.000 | 0.890 | 0.000 | 0.890 | 0.000 | 0.960 | 0.000 | 0.779 | 0.003 | Download |
| Daylight fingerprints | 0.700 | 0.000 | 0.820 | 0.000 | 0.760 | 0.000 | 0.748 | 0.004 | 0.810 | 0.000 | 0.528 | 0.004 | Download |
| ECFP2 fingerprints | 0.938 | 0.004 | 0.962 | 0.004 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.900 | 0.000 | Download |
| ECFP4 fingerprints | 0.930 | 0.000 | 0.970 | 0.003 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.901 | 0.003 | Download |
| ECFP6 fingerprints | 0.940 | 0.000 | 0.962 | 0.000 | 0.951 | 0.003 | 0.950 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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