Target name

P00918: Carbonic anhydrase 2


  Protein function

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

  Database links

Uniprot primary ID P00918
PDB ID 4E49 4ZWI 2AW1 4Q9Y 3K7K 1ZFQ 3P5A 4ZWZ 4ZWY 3N0N 1BV3 3M1K 1FQR 3M1Q 4Q6D 3M1W 1ZFK 3ZP9 1LG6 1BNN 3U7C 1LG5 1FQN 1FQL 1FQM 4Q49 4MO8 3P5L 3V5G 1CIM 1LGD 3CYU 3M14 3SBH 3SBI 5BRW 1CIN 4KUV 1CIL 3S9T 3ML2 2WEG 1BIC 3KKX 4Q90 2H15 2EU2 2EU3 3M1J 1UGF 4HBA
DrugBank ID DB01119 DB01144 DB01194 DB00695 DB01021 DB01031 DB00880
BioGrid ID 107215
GuidetoPHARMACOLOGY ID
PharmGKB ID PA25989
KEGG ID hsa:760
DIP ID
STRING ID 9606.ENSP00000285379
IntAct ID P00918
DMDM
BRENDA 4.2.1.1
Reactome R-HSA-1247673 R-HSA-1237044 R-HSA-1475029
SignaLink
BioCyc
Entrez Gene (Gene ID) 760
BindingDB P00918

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.910 0.000 0.910 0.000 0.910 0.000 0.960 0.000 0.819 0.003 Download
Estate fingerprints 0.910 0.000 0.930 0.005 0.920 0.000 0.920 0.000 0.970 0.000 0.840 0.000 Download
MACCS fingerprints 0.903 0.005 0.877 0.000 0.890 0.000 0.890 0.000 0.960 0.000 0.779 0.003 Download
Daylight fingerprints 0.700 0.000 0.820 0.000 0.760 0.000 0.748 0.004 0.810 0.000 0.528 0.004 Download
ECFP2 fingerprints 0.938 0.004 0.962 0.004 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.000 Download
ECFP4 fingerprints 0.930 0.000 0.970 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.901 0.003 Download
ECFP6 fingerprints 0.940 0.000 0.962 0.000 0.951 0.003 0.950 0.000 0.990 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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