Target name

P04626: Receptor tyrosine-protein kinase erbB-2


  Protein function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

  Database links

Uniprot primary ID P04626
PDB ID 3H3B 1OVC 1N8Z 1MFG 1MFL 2L4K 3RCD 1QR1 2KS1 4HRN 2A91 4HRL 4HRM 3N85 3WLW 3BE1 2JWA 4GFU 3PP0 1MW4 1S78 3MZW 3WSQ
DrugBank ID DB08916 DB05773 DB06366 DB01259 DB00072
BioGrid ID 108376
GuidetoPHARMACOLOGY ID 2019
PharmGKB ID PA27844
KEGG ID hsa:2064
DIP ID DIP-8N
STRING ID 9606.ENSP00000269571
IntAct ID P04626
DMDM 119533
BRENDA 2.7.10.1
Reactome R-HSA-416572 R-HSA-1251932 R-HSA-1358803 R-HSA-1257604 R-HSA-1250196 R-HSA-1963640 R-HSA-2219530 R-HSA-1306955 R-HSA-1963642 R-HSA-1227986 R-HSA-5673001
SignaLink P04626
BioCyc
Entrez Gene (Gene ID) 2064
BindingDB P04626

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.812 0.004 0.948 0.000 0.880 0.000 0.870 0.000 0.930 0.000 0.770 0.000 Download
Estate fingerprints 0.800 0.000 0.820 0.004 0.810 0.000 0.810 0.000 0.860 0.000 0.619 0.003 Download
MACCS fingerprints 0.820 0.000 0.782 0.000 0.801 0.003 0.810 0.000 0.900 0.000 0.610 0.000 Download
Daylight fingerprints 0.780 0.000 0.942 0.000 0.861 0.003 0.850 0.000 0.870 0.000 0.735 0.005 Download
ECFP2 fingerprints 0.871 0.003 0.947 0.000 0.909 0.003 0.900 0.000 0.960 0.000 0.812 0.004 Download
ECFP4 fingerprints 0.815 0.005 0.985 0.000 0.900 0.000 0.890 0.000 0.970 0.000 0.811 0.003 Download
ECFP6 fingerprints 0.782 0.004 0.996 0.000 0.889 0.003 0.872 0.004 0.970 0.000 0.790 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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