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E-mail: biomed@csu.edu.cn
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Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
| Uniprot primary ID | P04626 |
| PDB ID | 3H3B 1OVC 1N8Z 1MFG 1MFL 2L4K 3RCD 1QR1 2KS1 4HRN 2A91 4HRL 4HRM 3N85 3WLW 3BE1 2JWA 4GFU 3PP0 1MW4 1S78 3MZW 3WSQ |
| DrugBank ID | DB08916 DB05773 DB06366 DB01259 DB00072 |
| BioGrid ID | 108376 |
| GuidetoPHARMACOLOGY ID | 2019 |
| PharmGKB ID | PA27844 |
| KEGG ID | hsa:2064 |
| DIP ID | DIP-8N |
| STRING ID | 9606.ENSP00000269571 |
| IntAct ID | P04626 |
| DMDM | 119533 |
| BRENDA | 2.7.10.1 |
| Reactome | R-HSA-416572 R-HSA-1251932 R-HSA-1358803 R-HSA-1257604 R-HSA-1250196 R-HSA-1963640 R-HSA-2219530 R-HSA-1306955 R-HSA-1963642 R-HSA-1227986 R-HSA-5673001 |
| SignaLink | P04626 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2064 |
| BindingDB | P04626 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.812 | 0.004 | 0.948 | 0.000 | 0.880 | 0.000 | 0.870 | 0.000 | 0.930 | 0.000 | 0.770 | 0.000 | Download |
| Estate fingerprints | 0.800 | 0.000 | 0.820 | 0.004 | 0.810 | 0.000 | 0.810 | 0.000 | 0.860 | 0.000 | 0.619 | 0.003 | Download |
| MACCS fingerprints | 0.820 | 0.000 | 0.782 | 0.000 | 0.801 | 0.003 | 0.810 | 0.000 | 0.900 | 0.000 | 0.610 | 0.000 | Download |
| Daylight fingerprints | 0.780 | 0.000 | 0.942 | 0.000 | 0.861 | 0.003 | 0.850 | 0.000 | 0.870 | 0.000 | 0.735 | 0.005 | Download |
| ECFP2 fingerprints | 0.871 | 0.003 | 0.947 | 0.000 | 0.909 | 0.003 | 0.900 | 0.000 | 0.960 | 0.000 | 0.812 | 0.004 | Download |
| ECFP4 fingerprints | 0.815 | 0.005 | 0.985 | 0.000 | 0.900 | 0.000 | 0.890 | 0.000 | 0.970 | 0.000 | 0.811 | 0.003 | Download |
| ECFP6 fingerprints | 0.782 | 0.004 | 0.996 | 0.000 | 0.889 | 0.003 | 0.872 | 0.004 | 0.970 | 0.000 | 0.790 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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