Target name

P04629: High affinity nerve growth factor receptor


  Protein function

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

  Database links

Uniprot primary ID P04629
PDB ID 1WWW 4AOJ 4YPS 4PMT 4PMS 2IFG 1HE7 4PMM 1WWA 4F0I 4YNE 4CRP 4PMP 4GT5 1SHC
DrugBank ID DB00619 DB08896 DB00321
BioGrid ID 110969
GuidetoPHARMACOLOGY ID 1817
PharmGKB ID PA31817
KEGG ID hsa:4914
DIP ID DIP-5714N
STRING ID 9606.ENSP00000431418
IntAct ID P04629
DMDM 94730402
BRENDA 2.7.10.1
Reactome R-HSA-198745 R-HSA-167021 R-HSA-187706 R-HSA-170968 R-HSA-187042 R-HSA-170984 R-HSA-167044 R-HSA-177504 R-HSA-187024 R-HSA-198203
SignaLink P04629
BioCyc
Entrez Gene (Gene ID) 4914
BindingDB P04629

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.865 0.013 0.885 0.005 0.875 0.007 0.875 0.007 0.940 0.000 0.753 0.014 Download
Estate fingerprints 0.771 0.007 0.757 0.007 0.764 0.005 0.766 0.005 0.835 0.005 0.528 0.006 Download
MACCS fingerprints 0.812 0.010 0.762 0.006 0.787 0.007 0.792 0.008 0.861 0.003 0.574 0.013 Download
Daylight fingerprints 0.795 0.011 0.791 0.008 0.793 0.008 0.794 0.007 0.860 0.000 0.584 0.013 Download
ECFP2 fingerprints 0.892 0.008 0.878 0.007 0.885 0.005 0.887 0.005 0.961 0.003 0.772 0.010 Download
ECFP4 fingerprints 0.848 0.010 0.948 0.005 0.898 0.006 0.890 0.005 0.970 0.000 0.798 0.010 Download
ECFP6 fingerprints 0.815 0.008 0.965 0.005 0.890 0.005 0.882 0.006 0.970 0.000 0.792 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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