Target name

P05556: Integrin beta-1

  Protein function

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.

  Database links

Uniprot primary ID P05556
PDB ID 4WK2 4WK0 4DX9 4WJK 4WK4 1LHA 3VI3 3VI4 3G9W 1K11 3T9K
DrugBank ID DB00098
BioGrid ID 109894
PharmGKB ID PA29953
KEGG ID hsa:3688
STRING ID 9606.ENSP00000303351
IntAct ID P05556
DMDM 218563324
Reactome R-HSA-216083 R-HSA-445144 R-HSA-5663220 R-HSA-2129379 R-HSA-3000157 R-HSA-416700 R-HSA-1566948 R-HSA-210991 R-HSA-1566977 R-HSA-202733 R-HSA-3000178 R-HSA-3000170 R-HSA-446343 R-HSA-447041 R-HSA-75892 R-HSA-198933
SignaLink P05556
Entrez Gene (Gene ID) 3688
BindingDB P05556

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.919 0.003 0.937 0.000 0.928 0.004 0.928 0.004 0.969 0.003 0.850 0.000 Download
Estate fingerprints 0.958 0.004 0.892 0.000 0.925 0.005 0.930 0.000 0.979 0.003 0.854 0.005 Download
MACCS fingerprints 0.917 0.005 0.903 0.005 0.910 0.000 0.910 0.000 0.970 0.000 0.824 0.005 Download
Daylight fingerprints 0.845 0.005 0.955 0.000 0.900 0.000 0.900 0.000 0.950 0.000 0.810 0.000 Download
ECFP2 fingerprints 0.950 0.000 0.944 0.003 0.947 0.005 0.947 0.005 0.990 0.000 0.890 0.000 Download
ECFP4 fingerprints 0.950 0.000 0.982 0.003 0.966 0.005 0.965 0.005 0.990 0.000 0.931 0.003 Download
ECFP6 fingerprints 0.933 0.005 0.991 0.000 0.962 0.004 0.962 0.004 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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