Target name

P05979: Prostaglandin G/H synthase 1


  Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

  Database links

Uniprot primary ID P05979
PDB ID 1IGZ 1IGX 1FE2 2AYL 3KK6 1CQE 3N8W 3N8V 3N8Z 3N8Y 3N8X 1HT8 1EQH 1DIY 1EQG 1HT5 4O1Z 1EBV 1Q4G 1PTH 1PRH 1U67 1DJJ 2OYU 1PGF 1PGG 1PGE 2OYE
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID oas:443551
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA 1.14.99.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 443551
BindingDB P05979

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.895 0.005 0.831 0.003 0.863 0.005 0.869 0.003 0.939 0.003 0.726 0.007 Download
Estate fingerprints 0.866 0.007 0.808 0.007 0.837 0.005 0.844 0.005 0.900 0.000 0.681 0.009 Download
MACCS fingerprints 0.818 0.008 0.814 0.004 0.816 0.005 0.816 0.005 0.887 0.005 0.631 0.010 Download
Daylight fingerprints 0.762 0.008 0.818 0.006 0.790 0.005 0.782 0.004 0.820 0.000 0.581 0.006 Download
ECFP2 fingerprints 0.954 0.005 0.842 0.003 0.898 0.004 0.906 0.005 0.970 0.000 0.804 0.008 Download
ECFP4 fingerprints 0.959 0.006 0.881 0.003 0.920 0.007 0.922 0.006 0.979 0.003 0.843 0.013 Download
ECFP6 fingerprints 0.954 0.005 0.928 0.005 0.941 0.006 0.941 0.006 0.980 0.000 0.883 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn