Target name

P07384: Calpain-1 catalytic subunit


  Protein function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

  Database links

Uniprot primary ID P07384
PDB ID 2ARY 1ZCM
DrugBank ID
BioGrid ID 107273
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26057
KEGG ID hsa:823
DIP ID
STRING ID 9606.ENSP00000279247
IntAct ID P07384
DMDM 115574
BRENDA 3.4.22.53 3.4.22.52
Reactome R-HSA-1474228
SignaLink
BioCyc
Entrez Gene (Gene ID) 823
BindingDB P07384

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.929 0.003 0.891 0.005 0.910 0.000 0.911 0.003 0.950 0.000 0.826 0.005 Download
Estate fingerprints 0.920 0.000 0.826 0.005 0.873 0.005 0.880 0.000 0.940 0.000 0.752 0.004 Download
MACCS fingerprints 0.930 0.000 0.910 0.003 0.920 0.000 0.920 0.000 0.950 0.000 0.840 0.005 Download
Daylight fingerprints 0.886 0.005 0.902 0.004 0.894 0.005 0.894 0.005 0.930 0.000 0.790 0.008 Download
ECFP2 fingerprints 0.950 0.000 0.950 0.004 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.005 Download
ECFP4 fingerprints 0.950 0.000 0.970 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.918 0.004 Download
ECFP6 fingerprints 0.950 0.000 0.986 0.000 0.968 0.004 0.965 0.005 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn