TargetNet
  Target name

P07477: Trypsin-1

  Protein function

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

  Database links
Uniprot primary ID P07477
PDB ID 1FXY 2RA3 4WWY 1TRN 4WXV
DrugBank ID DB06692
BioGrid ID 111626
GuidetoPHARMACOLOGY ID 2397
PharmGKB ID PA33828
KEGG ID hsa:5644
DIP ID
STRING ID 9606.ENSP00000308720
IntAct ID P07477
DMDM 136408
BRENDA
Reactome R-HSA-1592389 R-HSA-196741
SignaLink
BioCyc
Entrez Gene (Gene ID) 5644
BindingDB P07477
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.881 0.003 0.879 0.000 0.880 0.000 0.880 0.000 0.940 0.000 0.760 0.000 Download
Estate fingerprints 0.910 0.000 0.910 0.005 0.910 0.000 0.910 0.000 0.960 0.000 0.819 0.003 Download
MACCS fingerprints 0.840 0.000 0.862 0.005 0.851 0.003 0.850 0.000 0.926 0.005 0.709 0.003 Download
Daylight fingerprints 0.838 0.004 0.882 0.003 0.860 0.000 0.858 0.004 0.930 0.000 0.718 0.004 Download
ECFP2 fingerprints 0.948 0.004 0.952 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.900 0.000 Download
ECFP4 fingerprints 0.950 0.000 0.970 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download
ECFP6 fingerprints 0.936 0.005 0.984 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.918 0.004 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn