Target name

P07943: Aldose reductase


  Protein function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

  Database links

Uniprot primary ID P07943
PDB ID
DrugBank ID
BioGrid ID 246382
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:24192
DIP ID
STRING ID 10116.ENSRNOP00000012879
IntAct ID
DMDM
BRENDA 1.1.1.21
Reactome R-RNO-196108 R-RNO-5652227
SignaLink
BioCyc
Entrez Gene (Gene ID) 24192
BindingDB P07943

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.780 0.013 0.918 0.005 0.849 0.006 0.837 0.007 0.930 0.000 0.706 0.012 Download
Estate fingerprints 0.911 0.003 0.901 0.006 0.906 0.005 0.906 0.005 0.960 0.000 0.809 0.006 Download
MACCS fingerprints 0.875 0.007 0.901 0.006 0.888 0.004 0.885 0.005 0.950 0.000 0.774 0.011 Download
Daylight fingerprints 0.682 0.010 0.828 0.010 0.755 0.008 0.736 0.008 0.857 0.005 0.519 0.014 Download
ECFP2 fingerprints 0.980 0.000 0.912 0.006 0.946 0.005 0.946 0.005 0.986 0.005 0.889 0.007 Download
ECFP4 fingerprints 0.975 0.005 0.925 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.899 0.003 Download
ECFP6 fingerprints 0.969 0.006 0.949 0.004 0.959 0.003 0.959 0.003 0.990 0.000 0.922 0.010 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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