Target name

P07949: Proto-oncogene tyrosine-protein kinase receptor Ret


  Protein function

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.

  Database links

Uniprot primary ID P07949
PDB ID 2X2L 2X2M 2X2K 4CKJ 4CKI 2IVU 2IVT 1XPD 4UX8 2IVS 2X2U 2IVV
DrugBank ID DB08875 DB08896 DB08901 DB00398
BioGrid ID 111911
GuidetoPHARMACOLOGY ID 2185
PharmGKB ID PA34335
KEGG ID hsa:5979
DIP ID DIP-41449N
STRING ID 9606.ENSP00000347942
IntAct ID P07949
DMDM 547807
BRENDA 2.7.10.1
Reactome
SignaLink P07949
BioCyc
Entrez Gene (Gene ID) 5979
BindingDB P07949

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.874 0.010 0.836 0.003 0.855 0.005 0.859 0.006 0.947 0.005 0.713 0.012 Download
Estate fingerprints 0.754 0.013 0.786 0.009 0.770 0.008 0.767 0.009 0.861 0.003 0.537 0.016 Download
MACCS fingerprints 0.862 0.012 0.750 0.010 0.806 0.005 0.816 0.005 0.890 0.000 0.614 0.005 Download
Daylight fingerprints 0.891 0.007 0.743 0.006 0.817 0.005 0.831 0.007 0.859 0.006 0.642 0.013 Download
ECFP2 fingerprints 0.943 0.007 0.803 0.012 0.873 0.007 0.883 0.007 0.949 0.003 0.752 0.013 Download
ECFP4 fingerprints 0.895 0.008 0.899 0.009 0.897 0.008 0.899 0.007 0.960 0.000 0.801 0.014 Download
ECFP6 fingerprints 0.835 0.008 0.949 0.007 0.892 0.004 0.886 0.005 0.951 0.003 0.791 0.010 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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