Target name

P08253: 72 kDa type IV collagenase


  Protein function

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.

  Database links

Uniprot primary ID P08253
PDB ID 1GEN 1CK7 1CXW 1KS0 1RTG 1HOV 1EAK 1QIB 1GXD 3AYU 1J7M
DrugBank ID DB00786 DB01197
BioGrid ID 110457
GuidetoPHARMACOLOGY ID 1629
PharmGKB ID PA30877
KEGG ID hsa:4313
DIP ID DIP-26N
STRING ID 9606.ENSP00000219070
IntAct ID P08253
DMDM 116856
BRENDA 3.4.24.24
Reactome R-HSA-1592389 R-HSA-381426 R-HSA-3928665 R-HSA-1474228 R-HSA-1442490
SignaLink
BioCyc MetaCyc:HS01565-MONOMER
Entrez Gene (Gene ID) 4313
BindingDB P08253

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.890 0.000 0.870 0.003 0.880 0.000 0.880 0.000 0.950 0.000 0.760 0.000 Download
Estate fingerprints 0.860 0.000 0.780 0.005 0.820 0.000 0.830 0.000 0.910 0.000 0.650 0.000 Download
MACCS fingerprints 0.810 0.000 0.870 0.000 0.840 0.000 0.830 0.000 0.930 0.000 0.672 0.004 Download
Daylight fingerprints 0.869 0.003 0.819 0.000 0.844 0.005 0.850 0.000 0.910 0.000 0.689 0.003 Download
ECFP2 fingerprints 0.940 0.000 0.920 0.005 0.930 0.000 0.930 0.000 0.980 0.000 0.860 0.000 Download
ECFP4 fingerprints 0.950 0.000 0.950 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.907 0.005 Download
ECFP6 fingerprints 0.926 0.005 0.954 0.000 0.940 0.000 0.940 0.000 0.980 0.000 0.889 0.003 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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