The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
| Uniprot primary ID | P08482 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 247270 |
| GuidetoPHARMACOLOGY ID | 13 |
| PharmGKB ID | |
| KEGG ID | rno:25229 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000024785 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-390648 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25229 |
| BindingDB | P08482 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.781 | 0.003 | 0.873 | 0.003 | 0.827 | 0.005 | 0.819 | 0.003 | 0.900 | 0.000 | 0.652 | 0.004 | Download |
| Estate fingerprints | 0.825 | 0.005 | 0.797 | 0.004 | 0.811 | 0.003 | 0.815 | 0.005 | 0.870 | 0.000 | 0.624 | 0.010 | Download |
| MACCS fingerprints | 0.879 | 0.003 | 0.773 | 0.003 | 0.826 | 0.005 | 0.835 | 0.005 | 0.890 | 0.000 | 0.655 | 0.005 | Download |
| Daylight fingerprints | 0.710 | 0.000 | 0.814 | 0.005 | 0.762 | 0.004 | 0.750 | 0.000 | 0.809 | 0.003 | 0.532 | 0.004 | Download |
| ECFP2 fingerprints | 0.888 | 0.004 | 0.892 | 0.004 | 0.890 | 0.000 | 0.890 | 0.000 | 0.960 | 0.000 | 0.781 | 0.006 | Download |
| ECFP4 fingerprints | 0.920 | 0.000 | 0.936 | 0.003 | 0.928 | 0.004 | 0.927 | 0.005 | 0.980 | 0.000 | 0.854 | 0.005 | Download |
| ECFP6 fingerprints | 0.902 | 0.006 | 0.946 | 0.000 | 0.924 | 0.005 | 0.920 | 0.000 | 0.970 | 0.000 | 0.847 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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