Target name

P08482: Muscarinic acetylcholine receptor M1


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

  Database links

Uniprot primary ID P08482
PDB ID
DrugBank ID
BioGrid ID 247270
GuidetoPHARMACOLOGY ID 13
PharmGKB ID
KEGG ID rno:25229
DIP ID
STRING ID 10116.ENSRNOP00000024785
IntAct ID
DMDM
BRENDA
Reactome R-RNO-390648 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 25229
BindingDB P08482

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.781 0.003 0.873 0.003 0.827 0.005 0.819 0.003 0.900 0.000 0.652 0.004 Download
Estate fingerprints 0.825 0.005 0.797 0.004 0.811 0.003 0.815 0.005 0.870 0.000 0.624 0.010 Download
MACCS fingerprints 0.879 0.003 0.773 0.003 0.826 0.005 0.835 0.005 0.890 0.000 0.655 0.005 Download
Daylight fingerprints 0.710 0.000 0.814 0.005 0.762 0.004 0.750 0.000 0.809 0.003 0.532 0.004 Download
ECFP2 fingerprints 0.888 0.004 0.892 0.004 0.890 0.000 0.890 0.000 0.960 0.000 0.781 0.006 Download
ECFP4 fingerprints 0.920 0.000 0.936 0.003 0.928 0.004 0.927 0.005 0.980 0.000 0.854 0.005 Download
ECFP6 fingerprints 0.902 0.006 0.946 0.000 0.924 0.005 0.920 0.000 0.970 0.000 0.847 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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